AC Milan vs Napoli Preview, prediction, lineups, betting tips & odds | Serie A 2025-26

The Partenopei emerged victorious when they last faced the Rossoneri.

AC Milan are all set to lock horns with SSC Napoli for their matchweek 5 contest of the Serie A 2025-26 season. This intense fixture between top Italian clubs will take place at the San Siro Stadium.

After losing their opening game of the new season, the Rossoneri have improved a lot and will be looking to continue their winning run. The Massimiliano Allegri-led side is coming in after securing a dominating win against Lecce in their previous fixture.

AC Milan will be keen on putting up a similar show in their next game, which is not going to be an easy task for them.

pic.twitter.com/AJx5T8vE0u

— AC Milan (@acmilan) September 24, 2025

SSC Napoli have done well in the Serie A but faced a defeat in their recent UEFA Champions League game against Manchester City. The Antonio Conte-led side were completely outplayed. They then made a strong comeback after defeating Pisa in their very next game. It became a close contest towards the end, but the Partenopei secured a 3-2 win.

Kick-off:

• Location: Milan, Italy
• Stadium: San Siro Stadium
• Date: Monday, September 29
• Kick-off Time: 12:15 a.m. IST (Sunday, Sept 28; 06:45 p.m. GMT/ 02:45 p.m. ET/ 11:45 a.m. PT)
• Referee: Daniele Chiffi
• VAR: In use

Form:

Milan: L-W-W-W-W

Napoli: W-W-W-L-W

Players to Watch

Christian Pulisic (AC Milan)

In four Serie A appearances this season, Christian Pulisic has scored three goals and also has an assist to his name. The American forward scored an important goal in the last league game as well, which helped AC Milan with an easy win. He is going to create issues for the opponent’s defence.

Iceman Puli ❄️ pic.twitter.com/wtEW1RiMzg

— AC Milan (@acmilan) September 24, 2025

Kevin De Bruyne (Napoli)

Despite not scoring any goals in the last game for SSC Napoli, the Belgian midfielder continues to regulate the ball well. Kevin De Bruyne has scored two goals in four games. He can build innovative plays for his fellow teammates, which can become a problem for AC Milan.

Match Facts

• Napoli have won both of their last two matches against the Rossoneri.
• AC Milan are on a four-match winning streak.
• The Partenopei have won four of their last five matches.

AC Milan vs Napoli: Betting Tips and Odds

• AC Milan to win @7/5 BetFred
• Christian Pulisic to score @7/1 bet365
• Goals over 3.5 @3/1 BetMGM

Injury and Team News

AC Milan will be without the services of Ardon Jashari as he is injured. Rafael Leao is back in training and might come on as a substitute.

Who asked for Rafa content? 😏🙋‍♂️ pic.twitter.com/eReke1oryu

— AC Milan (@acmilan) September 25, 2025

Romelu Lukaku, Nikita Contini, Pasquale Mazzocchi and Alessandro Buongiorno will not be in action for Napoli as they are injured.

Head-to-Head

Total matches: 172

AC Milan won: 69

Napoli won: 51

Draws: 52

Predicted Lineups

AC Milan predicted lineup (3-5-2)

Maignan (GK); Tomori, De Winter, Pavlovic; Saelemaekers, Modric, Ricci, Rabiot, Bartesaghi; Nkunku, Pulisic

Napoli predicted lineup (4-1-4-1)

Meret (GK); Di Lorenzo, Beukema, Buongiorno, Spinazzola; Gilmour; Politano, Elmas, De Bruyne, McTominay; Højlund

Match Prediction

These Italian giants are going to come up with an intense fixture. AC Milan are likely to emerge victorious against Napoli in their upcoming Serie A clash.

Prediction: AC Milan 3-2 Napoli

Telecast Details

India: DAZN

Italy: Sky Sports, DAZN

UK: DAZN

USA: Paramount+, DAZN

For more updates, follow Khel Now on Facebook, Twitter, and Instagram; download the Khel Now Android App or IOS App and join our community on Telegram.