Ajax vs Inter Milan Preview, prediction, lineups, betting tips & odds | UEFA Champions League 2025-26

Internazionale emerged victorious when these sides last met.

Ajax are all set to lock horns with Inter Milan in their matchweek 1 league phase fixture of the 2025-26 UEFA Champions League. The interesting fixture between these clubs is scheduled to take place at the Johan Cruijff Arena.

Ajax Amsterdam will be at home for their opening UCL game. They will be keen on using it to their advantage. They have started their season on a positive note.

The hosts have not faced a defeat in any of their first five league games of the new season. They will be looking to continue their form.

Inter Milan will be under some pressure as they are coming in after facing back-to-back defeats in Serie A. The Cristian Chivu-led side started with a dominating win, but came up with underwhelming performances in their next two league matches. They will be away from home and will also be seeking a different approach.

Kick-off:

• Location: Amsterdam, Netherlands
• Stadium: Johan Cruijff Arena
• Date: Thursday, September 18
• Kick-off Time: 12:30 a.m. IST (Wednesday, September 17; 07:00 p.m. GMT/ 03:00 p.m. ET/ 12:00 p.m. PT)
• Referee: Michael Oliver
• VAR: In use

Form:

Ajax: W-D-W-D-W

Inter: W-L-L

Players to Watch

Wout Weghorst (Ajax)

The Dutch striker will be looking to step up as Ajax are going to face a tough challenge in their upcoming fixture. Wout Weghorst has scored three goals and has an assist to his name in five league appearances for his side. He is going to play a crucial part in the final third for the hosts.

Marcus Thuram (Inter Milan)

Marcus Thuram will have an essential role to play in the attacking front for Inter Milan. He is coming in after scoring a goal in the last league game for his side. The Frenchman has started a new season in positive form and will be looking to continue with it coming into the Champions League.

🫡 @MarcusThuram fa 2-3! #JuveInter pic.twitter.com/1y0xechLxW

— Lega Serie A (@SerieA) September 13, 2025

Match Facts

• FC Internazionale Milano are on a two-match losing streak.
• AFC Ajax are on a five-match undefeated run.
• De Godenzonen are yet to secure a win against Inter.

Ajax vs Inter Milan: Betting Tips and Odds

• Inter Milan to win @10/11 BetFred
• Marcus Thuram to score @6/1 Skybet
• Goals over 3.5 @37/20 BetMGM

Injury and Team News

AFC Ajax might miss out on the services of Aaron Bouwman and Branco van den Boomen due to a lack of fitness.

Inter Milan have all their players fit and ready to be in action.

Head-to-Head

Total matches: 5

Ajax won: 0

Inter won: 2

Draws: 3

Predicted Lineups

Ajax predicted lineup (4-3-3)

Jaros (GK); Gaaei, Itakura, Baas, Wijndal; Regeer, Taylor, Klaassen; Berghuis, Weghorst, Godts

Inter Milan predicted lineup (3-5-2)

Sommer (GK); Akanji, Acerbi, Bastoni; Dumfries, Barella, Çalhanoglu, Mkhitaryan, Augusto; Thuram, Martinez

Match Prediction

These clubs will face each other after a long time. Hence, it is going to be an interesting fixture. Inter Milan are likely to defeat AFC Ajax in their upcoming UEFA Champions League clash.

Prediction: Ajax 1-3 Inter

Telecast Details

India: SonyLIV, Sony Sports Network

UK: TNT Sports, BBC

US: Paramount+, TUDN

Nigeria: DAZN

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