Inter Milan vs Sassuolo Preview, prediction, lineups, betting tips & odds | Serie A 2025-26

The Neroverdi emerged victorious when they last faced Internazionale.

Inter Milan are all set to host Sassuolo for their matchweek 4 of the Serie A 2025-26 season. The San Siro Stadium is all set to witness an interesting contest between the two clubs.

FC Internazionale Milano will be at home for their upcoming league fixture. It is going to be an advantage for them. The Christian Chivu-led side have lost both of their last two Serie A games.

They failed to perform up to their standards. However, Inter Milan are coming into the game after securing a 2-0 win against Ajax in their UCL fixture.

Prep mode 🔛#ForzaInter pic.twitter.com/YEu1SRgWBr

— Inter ⭐⭐ (@Inter) September 19, 2025

Despite being the visiting team, the Neroverdi will be feeling confident because of their last couple of results against Internazionale. They are coming in after taking down Lazio in their last league game. It was a close fixture for them, but they did enough to secure three important points.

Kick-off:

• Location: Milan, Italy
• Stadium: San Siro Stadium
• Date: Monday, September 22
• Kick-off Time: 12:15 a.m. IST (Sunday, Sept 21; 06:45 p.m. GMT/ 02:45 p.m. ET/ 11:45 a.m. PT)
• Referee: Livio Marinelli
• VAR: In use

Form:

Inter Milan: W-L-L-W

Sassuolo: W-L-L-W

Players to Watch

Marcus Thuram (Inter Milan)

Marcus Thuram looks in good touch and is going to play an important role in the attacking front for FC Internazionale Milano. The Frenchman is coming in after scoring a brace for his side in the last fixture. He single-handedly helped his side secure a win in their first Champions League match this season.

Same move. Same finish 🔥They pulled it off again 🤯#ForzaInter #UCL #AjaxInterpic.twitter.com/B1pAn2AUoH

— Inter ⭐⭐ (@Inter_en) September 19, 2025

Andrea Pinamonti (Sassuolo)

Andre Pinamonti will have an essential role to fulfil in the upcoming league fixture. He will be looking to step up, and while being in the final third, he will be looking to cause issues for the opponent’s defence. In three Serie A games this season, he has scored one goal.

Match Facts

• The Neroverdi have both of their last two games against Inter Milan.
• Internazionale are on a two-match losing run in the Serie A.
• Inter Milan have won three of their last five matches against Sassuolo.

Inter Milan vs Sassuolo: Betting Tips and Odds

• Inter Milan to win @2/7 William Hill
• Marcus Thuram to score @9/2 Skybet
• Goals under 3.5 @4/7 bet365

Injury and Team News

Matteo Darmian might miss out on for Inter Milan due to a lack of fitness.

Sassuolo are likely to be without Laurs Skjellerup and Sebastian Walukiewicz due to their fitness issues.

Head-to-Head

Total matches: 24

Inter Milan won: 11

Sassuolo won: 11

Draws: 2

Predicted Lineups

Inter Milan predicted lineup (3-5-2)

Sommer (GK); Akanji, De Vrij, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Thuram, Martinez

Sassuolo predicted lineup (4-3-3)

Muric (GK); Walukiewicz, Idzes, Muharemovic, Doig; Vranckx, Matic, Kone; Berardi, Pinamonti, Laurienté

Match Prediction

Even though the last two fixtures have ended in favour of the Neroverdi, Internazionale will not be looking to back down. Inter Milan are likely to come out on top to secure a win against Sassuolo in their upcoming Serie A clash.

Prediction: Inter 2-1 Sassuolo

Telecast Details

India: DAZN

Italy: Sky Sports, DAZN

UK: DAZN

USA: Paramount+, DAZN

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