Lazio vs AC Milan Preview, prediction, lineups, betting tips & odds | Coppa Italia 2025-26

The Rossoneri have secured three wins in their last five matches against Le Aquile.

SS Lazio are now gearing up to take on AC Milan for their round of 16 fixture of the 2025-26 Coppa Italia. This is going to be an intense battle between these clubs, which is scheduled to take place at the Stadio Olimpico.

Le Aquile have recently faced a defeat against AC Milan in their Serie A outing. This time around, they will face them in the Italian cup competition fixture. The hosts have not been very consistent with their performances, and this can become a problem for them.

Lazio have come up with average efforts in the league this season. They will need a top performance here if they want to get to the next stage of the cup tournament.

The Rossoneri have performed really well this season, and they will be keen to continue their run of form here. They have already defeated Lazio in their last league game and will be looking for a similar outcome in their Coppa Italia contest. Despite being away from home, Milan will be high on confidence.

Mondays should always feel like this 😁Brought to you by @play_eFootball pic.twitter.com/p8sv5xLCEN

— AC Milan (@acmilan) December 1, 2025

Kick-off:

• Location: Roma, Italy
• Stadium: Stadio Olimpico
• Date: Friday, December 5
• Kick-off Time: 01:30 a.m. IST (Thursday, Dec 4; 08:00 p.m. GMT/ 03:00 p.m. ET/ 12:00 p.m. PT)
• Referee: Marco Guida
• VAR: In use

Form:

Lazio: D-W-L-W-L

Milan: D-W-D-W-W

Players to Watch

Mattia Zaccagni (Lazio)

Mattia Zaccagni will be looking to step up his game so that he can help the hosts get past Milan. He failed to score a goal in the previous fixture for Lazio, but remains an important asset in the attacking front for SS Lazio. Zaccagni will be looking to come up with a top performance to help his side prevail against Milan this time around.

Rafael Leao (AC Milan)

The Portuguese forward is going to play a crucial part in the attacking front for the Rossoneri. He scored the match-winning goal against Lazio in Serie A and will be looking to find the net in Coppa Italia as well now. Rafael Leao has come up with some good performances for AC Milan this season.

Rafa tucks home a brilliant team goal 😮🤝 Brought to you by @SN4IFUN pic.twitter.com/SuTmo78AgW

— AC Milan (@acmilan) November 30, 2025

Match Facts

• AC Milan are undefeated in their last 13 matches.
• Lazio have won two of their last five games.
• Only one of the last five outings between these clubs has ended in a draw.

Lazio vs Milan: Betting Tips and Odds

• AC Milan to win @6/5 Unibet
• Rafael Leao to score @5/2 Quinnbet
• Goals under 3.5 @1/4 BetMGM

Injury and Team News

SS Lazio will miss out on the services of Danilo Cataldi. He is injured. Nicolo Rovella, Matteo Cancillieri and Samuel Gigot might also miss out due to their fitness issues.

Christian Pulisic, Santiago Gimenez and Zachary Athekame will not be in action for AC Milan. They are injured.

Head-to-Head

Total matches: 193

Lazio won: 41

Milan won: 87

Draws: 65

Predicted Lineups

Lazio predicted lineup (4-3-3)

Provedel (GK); Marusic, Gila, Romagnoli, Pellegrini; Guendouzi, Vecino, Basic; Isaksen, Castellanos, Zaccagni

AC Milan predicted lineup (3-5-2)

Maignan (GK); Tomori, Gabbia, Pavlovic; Saelemaekers, Fofana, Modric, Rabiot, Bartesaghi; Nkunku, Leao

Match Prediction

These clubs are going to put up an intense fixture against one another. We predict that AC Milan are likely to secure a win against SS Lazio in their upcoming Coppa Italia clash.

Prediction: Lazio 1-2 Milan

Telecast Details

India: DAZN

USA: Paramount+

UK: Premier Sports

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