Lazio vs AS Roma Preview, prediction, lineups, betting tips & odds | Serie A 2025-26

These clubs battled to a 1-1 draw when they last met.

SS Lazio are all set to lock horns with AS Roma in their Serie A 2025-26 matchweek 4 fixture. Stadio Olimpico is all set to witness the interesting clash between the two Italian clubs.

Lazio have not been able to start their new season with the best of performances. They fell prey to Como in their opening league fixture, but then made a strong comeback. They secured an easy win against Hellas Verona.

However, they faced a defeat at the hands of Sassuolo in their previous game. Due to this, Lazio have failed to build significant momentum.

After winning their first two games of the new Serie A season, AS Roma fell prey to Torino in their previous fixture. It was an underwhelming performance by them. It is likely to keep them under pressure in the next fixture.

The next league game is not going to be an easy one for them.

Kick-off:

• Location: Rome, Italy
• Stadium: Stadio Olimpico
• Date: Sunday, September 21
• Kick-off Time: 04:00 p.m. IST/ 10:30 a.m. GMT/ 06:30 a.m. ET/ 03:30 a.m. PT
• Referee: Simone Sozza
• VAR: In use

📘 Scarica gratuitamente il match program di #LazioRoma! ➡️ https://t.co/73XAAjK7tP#AvantiLazio pic.twitter.com/zMGaeNzcDz

— S.S.Lazio (@OfficialSSLazio) September 19, 2025

Form:

Lazio: L-W-L

Roma: W-W-L

Players to Watch

Valentin Castellanos (Lazio)

The 26-year-old forward is going to play an important role in the attacking front for SS Lazio in the upcoming Serie A game. Valentin Castellanos has three goal contributions in three league games in the new season. He will be looking to come up with another good performance here.

Matias Soule (AS Roma)

The Argentine will be looking to step up and get back in form. Even though Matias Soule failed to score a goal in the previous league game, he is still going to cause issues for the opponent’s defence. He has come up with some valuable performances in the past and will be keen on finding the net in the upcoming game.

Match Facts

• Two of the last three games between these clubs have ended in favour of Roma.
• Lazio have only won one of their last five fixtures against AS Roma.
• Both clubs are coming in after facing a defeat in their last Serie A matches.

Lazio vs Roma: Betting Tips and Odds

• Match to end in a draw @11/5 Coral
• Matias Soule to score @10/1 Unibet
• Goals under 2.5 @13/20 Ladbrokes

Injury and Team News

Lazio will miss out on the services of Manuel Lazzari as he is injured. They might also miss out on Patric, Samuel Gigot and Matias Vecino due to a lack of fitness.

Paulo Dybala will miss out due to an injury. Edoardo Bove will not be in action for AS Roma due to a heart problem. Leon Bailey might also miss out due to fitness issues.

Head-to-Head

Total matches: 184

Lazio won: 51

AS Roma won: 70

Draws: 63

Predicted Lineups

Lazio predicted lineup (4-3-3)

Provedel (GK); Marusic, Gila, Romagnoli, Tavares; Guendouzi, Rovella, Dele-Bashiru; Cancellieri, Castellanos, Zaccagni

AS Roma predicted lineup (3-4-1-2)

Svilar (GK); Hermoso, Mancini, Ndicka; França, Koné, Cristante, Angeliño; El Aynaoui; Soulè, Dovbyk

Match Prediction

These clubs have produced some close fixtures in the past, and we might be in for one yet again. The upcoming Serie A clash between Lazio and AS Roma is likely to end in a draw.

Prediction: Lazio 1-1 AS Roma

Telecast Details

India: DAZN

Italy: Sky Sports, DAZN

UK: DAZN

USA: Paramount+, DAZN

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