Liverpool vs Southampton Preview, prediction, lineups, betting tips & odds | EFL Cup 2025-26

The Reds secured an easy win when these sides last met.

Liverpool are all set to battle it out against Southampton in the third round fixture of the 2025-26 EFL Cup. The interesting and intense game between these clubs will take place at Anfield.

The Arne Slot-led side are in flying form and will be looking to continue their winning run here. For Liverpool, it is their first fixture of the English Carabao Cup this season and they will be keen on securing a win here. The Reds have been performing with consistency since the start of the season.

The Saints will be in for a tough contest. Firstly, they will be away from home and their efforts in their last few matches against Liverpool FC have been poor. Southampton have not been able to perform well this season and this will keep them under pressure from the start.

Kick-off:

• Location: Liverpool, England
• Stadium: Anfield
• Date: Wednesday, September 24
• Kick-off Time: 12:30 a.m. IST (Tuesday, Sept 23; 07:00 p.m. GMT/ 03:00 p.m. ET/ 12:00 p.m. PT)
• Referee: Thomas Bramall
• VAR: Not in use

Form:

Liverpool: W-W-W-W-W

Southampton: L-W-D-D-L

Players to Watch

Hugo Ekitike (Liverpool)

The 23-year-old forward from France yet again found the net in the last Premier League game. In five EPL appearances this season, Hugo Ekitike has scored three goals and also an assist to his name. He is going to cause problems for the opponent’s defence in the upcoming fixture.

Liverpool get Kansas City and Premier League Mornings Live rocking 🔥 pic.twitter.com/vpHWa1EB86

— Premier League USA (@PLinUSA) September 20, 2025

Adam Armstrong (Southampton)

Adam Armstrong will be looking to step up as the upcoming fixture is not going to be an easy affair for the Saints. He scored a goal in his last EFL Championship game for Southampton, but it was not enough to help them secure a win.

Match Facts

• Liverpool are on a four-match winning run against the Saints.
• Southampton are on a two-match winless streak.
• The Reds have won all of their last five matches.

Liverpool vs Southampton: Betting Tips and Odds

• Hugo Ekitike to score @15/4 bet365
• Liverpool to win @1/7 William Hill
• Goals over 3.5 @4/5 Spread Ex

Injury and Team News

Liverpool might miss out on the services of Stefan Bajcetic due to a lack of fitness.

Welington will not be in action for Southampton as he is injured. Samuel Edozie might also miss out due to fitness issues.

Head-to-Head

Total matches: 42

Liverpool won: 24

Southampton won: 10

Draws: 8

Predicted lineup

Liverpool predicted lineup (4-2-3-1)

Mamardashvili (GK); Frimpong, Konaté, Van Dijk, Robertson; Endo, Jones; Chiesa, Writz, Ngumoha; Ekitike

Southampton predicted lineup (4-2-3-1)

Bazunu (GK); Roerslev, Harwood-Bellis, Stephens, Manning; Jander, Charles; Fellows, Azaz, Fraser; Armstrong

Match Prediction

The Reds are in brilliant form and this will keep the Saints under pressure. Liverpool are likely to come out on top and secure a win against Southampton in their upcoming EFL Cup clash.

Prediction: Liverpool 3-1 Southampton

Telecast Details

India: FanCode

UK: Sky Sports Football

US: Paramount+

Nigeria: SuperSport

For more updates, follow Khel Now on Facebook, Twitter, and Instagram; download the Khel Now Android App or IOS App and join our community on Telegram.