Napoli vs Pisa Preview, prediction, lineups, betting tips & odds | Serie A 2025-26

Gli Azzurri have won all three games in the Serie A so far, while Pisa have yet to win a game.

Napoli, the defending Serie A champions, will host Pisa in their next match in the league at the Diego Armando Maradona Stadium.

Gil Azzuri are in sensational form in the Serie A. They have won all three matches that they have played so far. They are currently first in the points table with nine points, have scored six goals, and conceded just one.

Antonio Conte uses an adaptable system at Napoli, which focuses on high-pressure, quick transition, and recovering possession in dangerous areas.

⏹️ Full time#ManCityNapoli 2-0💙 #ForzaNapoliSempre pic.twitter.com/2pbsGUU8HY

— Official SSC Napoli (@en_sscnapoli) September 18, 2025

Pisa, returning to Serie A after 34 years, have had a challenging start to the season. They have just one point from their opening three matches and are currently sitting in 18th position. Their only goal so far was an own goal against Atalanta.

I Nerazzurri have suffered defeats against AS Roma and Udinese. Under Alberto Gilardino, Pisa rely on fast counterattacks and dangerous set-piece routines.

Kick-off:

• Location: Naples, Italy
• Stadium: Stadio Diego Armando Maradona
• Date: Tuesday, September 23
• Kick-Off Time: 12:15 AM IST
• Referee: Valerio Crezzini
• VAR: In Use

Form:

Napoli: W-W-W

Pisa: L-L-D

Players to watch out for:

Kevin De Bruyne (Napoli):

All the focus will be on Napoli’s recent signing of the summer, Kevin De Bruyne. The Belgian midfielder was subbed off early, due to tactical changes, in the recent 2-0 defeat against Manchester City. His experience, playmaking creativity, and ability to score in decisive moments make him an important player for this game.

🎥 Rivedi la conferenza stampa di presentazione di Kevin De Bruyne💙 #ProudToBeNapolihttps://t.co/KZKrupRdnu

— Official SSC Napoli (@sscnapoli) July 19, 2025

Matteo Tramoni (Pisa):

Pisa have had a tough start to the Serie A season, but the focus will be on their attacker, Matteo Tramoni. He will have the responsibility of creating opportunities and troubling the defence of the hosts. If Pisa need to score in this game, then Tramoni has to show his impact in this game.

Match Facts:

• Napoli have a perfect 3-0 record this Serie A season and will have the home advantage against Pisa. In contrast, Pisa have struggled on the road and remain winless with a W0-D1-L2 record.
• Pisa have only scored one goal in their first three league matches, and that was an own goal forced by an opponent. They will face a formidable Napoli defence that has only conceded a single goal all season.
• After being substituted early in a Champions League defeat, Kevin De Bruyne will be motivated and rested for the match, posing a significant creative threat to Pisa.

Napoli vs Pisa: Betting Tips and Odds:

• Napoli to win to nil: 9/2 from Bet365.
• Both teams to score – No: 8/15 from 1Win.
• Total goals under 2.5: 1.56 as per 1xBet.

Injuries and Team News:

Nikita Contini, Amir Rrahmani, and Romelu Lukaku will miss this game for the hosts.

Juan Cuadrado will miss this game for Pisa.

Head-To-Head Stats:

Total matches: 14

Napoli won: 10

Pisa won: 1

Draws: 3

Predicted Starting Lineup:

Napoli Predicted Starting Lineup (4-1-4-1):

Milinkovic-Savic; Di Lorenzo, Beukema, Buongiorno, Spinazzola; Lobotka; Politano, McTominay, Anguissa, De Bruyne; Hojlund

Pisa Predicted Starting Lineup (3-4-2-1):

Semper; Canestrelli, Cariaccolo, Lusuardi; Toure, Akinsanmiro, Aebischer, Angori; Moreo, Tramoni; Meister

Match Prediction:

Napoli are clearly the dominant side for this game, and Pisa are no match for the defending champions’ squad. Their strong defence and efficient attack, combined with the home advantage at the Diego Armando Maradona Stadium, make the hosts heavy favourites. 

Prediction: Napoli 2-0 Pisa

Telecast Details

India: DAZN

Italy: Sky Sports, DAZN

UK: DAZN

USA: Paramount+, DAZN

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