Preview: Napoli vs Sassuolo Prediction, lineups, betting tips & odds | Serie A 2025-26

The previous outing between these clubs ended in favour of the Antonio Conte-led side.
SSC Napoli are all set to lock horns with Sassuolo for their matchweek 21 fixture of the 2025-26 Serie A. This is going to be an entertaining game, taking place at the Diego Armando Maradona Stadium.
The Antonio Conte-led side are coming in after securing a goalless draw against Parma in their last league outing. It was not a top-notch effort by them, as they dropped points.
SSC Napoli are on third place on the league table at the moment. They must secure a win in their upcoming contest if they want to stay in the fight to defend their league title.
Sassuolo have performed poorly in their last five matches. They are likely to struggle in their next matchup due to their current run of form.
They are placed 11th on the Serie A points table. The Neroverdi have only won six of their 20 league clashes this season. The team must work on their strategy.
Kick-off:
- Location: Naples, Italy
- Stadium: Diego Armando Maradona Stadium
- Date: Saturday, January 17
- Kick-off Time: 10:30 p.m. IST/ 05:00 p.m. GMT/ 12:00 p.m. ET/ 09:00 a.m. PT
- Referee: TBD
- VAR: In use
Form:
Napoli: W-W-D-D-D
Sassuolo: L-D-D-L-L
Players to Watch
Rasmus Højlund (Napoli)

Even though he failed to score a goal in the previous league game for SSC Napoli, Rasmus Højlund will have a crucial role to play in the attacking front. In 16 Serie A appearances this season, the 22-year-old has scored six goals and has two assists to his name. He is going to be a constant threat to the opponent’s defence.
Andrea Pinamonti (Sassuolo)
Andrea Pinamonti will be looking to step up his game so that he can help his side stand a chance against Gli Azzurri. He also failed to score a goal for his team in the previous game, but is still going to play an important role up front. He has six goal involvements in 19 league games of the ongoing campaign.
Match Facts
- Napoli are undefeated in their last five matches.
- Sassuolo have failed to secure a win in their last five attempts.
- The Azzurri are on a six-match winning streak against the Neroverdi.
Napoli vs Sassuolo: Betting Tips and Odds
- Napoli to win @5/11 Unibet
- Rasmus Højlund to score @13/8 SkyBet
- Goals under 3.5 @3/10 bet365
Injury and Team News
Kevin De Bruyne, Romelu Lukaku, Billy Gilmour, Alex Meret and Andre-Frank Zambo Anguissa are not going to be in action for Napoli. They are injured.
Sassuolo will miss out on the services of Cristian Volpato, Kristian Thorstvedt, Domenico Berardi and Filippo Romagna due to their injuries. Edoardo Pieragnolo, Fali Cande and Daniel Boloca might also miss out due to a lack of fitness.
Head-to-Head
Total matches: 24
Napoli won: 15
Sassuolo won: 2
Draws: 7
Predicted Lineups
Napoli predicted lineup (3-4-2-1)
Milinkovic-Savic (GK); Di Lorenzo, Rrahmani, Buongiorno; Mazzocchi, Lobotka, McTominay, Spinazzola; Politano, Lucca; Hojlund
Sassuolo predicted lineup (4-3-3)
Muric (GK); Walukiewicz, Idzes, Muharemovic, Doig; Lipani, Matic, Kone; Fadera, Pinamonti, Laurienté
Match prediction
Both of these clubs will be looking for a win here, but it’s going to be SSC Napoli. They are likely to outshine Sassuolo in their upcoming Serie A clash.
Prediction: Napoli 2-0 Sassuolo
Telecast Details
India: DAZN
Italy: Sky Sports, DAZN
UK: DAZN
USA: Paramount+, DAZN
When and where is the Napoli vs Sassuolo Serie A match?
Saturday, January 17, 2026, at the Diego Armando Maradona Stadium in Naples. Kick-off is scheduled for 5:00 p.m. GMT.
Where and how to watch Serie A 2025-26 live in India?
DAZN have the rights to telecast the top flight of Italian football in India as of now.
Where and how to watch Serie A 2025-26 live in Italy?
Fans in the host nation can tune into Sky Sports and DAZN to watch all the fixtures live.
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Dilpreet is a dedicated football writer with a keen eye for World Football. As a proud Real Madrid fan, we believe his work reflects the same ambition and precision. Since joining Khel Now in 2025, he has crafted stories beyond scores, diving into tactics, culture, and emotion. With a strong background in content writing, he blends clarity with creativity, always aiming to bring the beautiful game closer to readers.