Preview: Panathinaikos vs Real Betis Prediction, lineups, betting tips & odds | UEFA Europa League 2025-26 Round of 16 first leg

These clubs are going to take on one another for the first time.
Panathinaikos are now going to take on Real Betis for their first leg round of 16 fixture of the 2025-26 UEFA Europa League. The Athens Olympic Stadium is going to witness this interesting clash.
The Shamrock will be at home and will be keen to use these conditions to their advantage. They have secured back-to-back wins in their last three matches and will be looking to extend their winning run.
The upcoming European competition fixture is not going to be an easy one for Panathinaikos. The visitors are likely to put up a strong fight.
Real Betis haven’t been able to perform to their full potential in their last three matches. This can become a problem for them going into their next UEFA Europa League clash.
They will be away from home and might keep them under some pressure from the start. Los Verdiblancos have capable players in the squad, and they will be looking to return to winning ways.
Kick-off:
- Location: Athens, Greece
- Stadium: Athens Olympic Stadium
- Date: Thursday, March 12
- Kick-off Time: 11:15 p.m. IST/ 05:45 p.m. GMT/ 12:45 p.m. ET/ 09:45 a.m. PT
- Referee: TBA
- VAR: In use
Form:
Panathinaikos: W-D-W-W-W
Real Betis: W-W-D-D-L
Players to Watch
Andrews Tetteh (Panathinaikos)
Andrews Tetteh has been one of the crucial aspects in the final third for Panathinaikos. He has been consistent with his performances in the last five games for his club and will be eager to come up with another top show. The 24-year-old has scored three goals in the European competition this season.
Antony (Real Betis)

Despite failing to score in the previous LaLiga fixture for Real Betis, Antony remains an important aspect for them in the attacking front. He is in decent form this season and will once again lead the attack from the right for his side. In just six UEFA Europa League fixtures, the 26-year-old has seven goal involvements.
Match Facts
- Panathinaikos are on a three-match winning streak.
- Real Betis are winless in their last three matches.
- This will be the first-ever clash between these clubs.
Panathinaikos vs Real Betis: Betting Tips and Odds
- Real Betis to win @23/20 Coral
- Antony to score @3/1 BetVictor
- Goals under 3.5 @3/13 Unibet
Injury and Team News
Panathinaikos will miss out on the services of Cyriel Dessers, Pedro Chirivella, Giannis Kotsiras, Erik Palmer-Brown, Manolis Siopis and Sverrir Ingi Ingason due to their injuries. Javi Hernandez, Anastasios Bakasetas and Ahmed Touba are suspended.
Isco and Giovani Lo Celso are not going to be in action for Real Betis. They are injured. Jose Antonio Morante is suspended. Sofyan Amrabat is back in training.
Head-to-Head
Total matches: 0
Panathinaikos won: 0
Real Betis won: 0
Draws: 0
Predicted Lineups
Panathinaikos predicted lineup (3-4-2-1)
Lafont (GK); Katris, Jedvaj, Katris; Calabria, Kontouris, Cerin, Kyriakopoulos; Taborda, Zaroury; Tetteh
Real Betis predicted lineup (4-3-3)
Valles (GK); Ruibal, Llorente, Natan, Rodriguez; Fornals, Roca, Altimira; Antony, Hernandez, Ezzalzouli
Match Prediction
Neither of these clubs will be looking to back down. They are going to come up with an interesting game. Real Betis are likely to outshine Panathinaikos in their upcoming round of 16 battle in the UEFA Europa League.
Prediction: Panathinaikos 1-2 Real Betis
Telecast Details
India: SonyLIV, Sony Sports Network
UK: TNT Sports
US: Paramount+, TUDN
Middle East/North Africa: beIN Sports
When and where is Panathinaikos vs Real Betis Europa League match?
Thursday, March 12, 2026, at the Athens Olympic Stadium in Athens, Greece. Kick-off is scheduled for 5:45 p.m. GMT.
Where and how to watch Europa League live in India?
Sony Liv and Sony Sports Network will come up with the live streaming of all matches.
Where and how to watch Europa League live in UK?
TNT Sports will stream all the games for the fans in the United Kingdom.
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Dilpreet is a dedicated football writer with a keen eye for World Football. As a proud Real Madrid fan, we believe his work reflects the same ambition and precision. Since joining Khel Now in 2025, he has crafted stories beyond scores, diving into tactics, culture, and emotion. With a strong background in content writing, he blends clarity with creativity, always aiming to bring the beautiful game closer to readers.