PSV Eindhoven vs Napoli Preview, prediction, lineups, betting tips & odds | UEFA Champions League 2025-26

The previous confrontation between these clubs ended in favour of the Rood-witten.
PSV Eindhoven are all set to battle it out against SSC Napoli for their league phase third round fixture of the UEFA Champions League 2025-26 edition. Philips Stadion will witness this interesting clash.
The Rood-witten at home will be looking for their first win of the current UCL campaign. They fell prey to Union St.-Gilloise in their opening game of the European competition. PSV Eindhoven were held to a 1-1 draw against Bayer Leverkusen in their last fixture. They are going to be at home for their next one and will be keen on using it to their advantage.
The Partenopei are coming in after their shocking defeat against Torino FC in their Serie A fixture. This might bring down their confidence levels. Their performance in the ongoing UEFA Champions League has been average. SSC Napoli lost their first fixture against Manchester City, but made a comeback after defeating Sporting CP.
Kick-off:
- Location: Eindhoven, Netherlands
- Stadium: Philips Stadion
- Date: Wednesday, October 22
- Kick-off Time: 12:30 a.m. IST (Tuesday, Oct 21; 07:00 p.m. GMT/ 03:00 p.m. ET/ 12:00 p.m. PT)
- Referee: Daniel Siebert
- VAR: In use
Form:
PSV: D-W-D-W-W
Napoli: W-L-W-W-L
Players to Watch
Guus Til (PSV)
Guus Til is coming in after scoring a brace for his side in their previous league game. PSV secured a win only because of the goals scored by Til. He is going to play a crucial role in the final third for PSV in their upcoming fixture. With the help of his fellow teammates, he can cause issues for Napoli.
Rasmus Hojlund (Napoli)

The Denmark international will be one of the important assets for Napoli in the attacking front. Rasmus Hojlund was not a part of the squad in the previous fixture and the Partenopei faced a defeat. His performance in the last few matches for club and country has been good. He is going to be a constant threat to the opponent’s defence.
Match Facts
- Napoli haven’t been able to keep a clean sheet in their last seven matches.
- PSV Eindhoven are unbeaten in their last five fixtures.
- The Rood-witten are undefeated against the Partenopei.
PSV vs Napoli: Betting Tips and Odds
- Napoli to win @6/5 bet365
- Rasmus Hojlund to score @15/2 Unibet
- Goals under 3.5 @1/2 bet365
Injury and Team News
PSV will miss out on the services of Ruben van Bommel as he is injured. Alassane Plea and Kilian Sldillia might also miss out due to a lack of fitness.
Romelu Lukaku, Stanislav Lobotka, Amir Rrahmani and Nikita Contini are injured and will not be in action for Napoli.
Head-to-Head
Total matches: 2
PSV won: 2
Napoli won: 0
Draws: 0
Predicted Lineups
PSV predicted lineup (4-2-3-1)
Kovar (GK); Dest, Schouten, Gasiorowski, Salah-Eddine; Mauro Júnior, Veerman; Man, Saibari, Perisic; Til
Napoli predicted lineup (4-1-4-1)
Milinkovic-Savic (GK); Di Lorenzo, Beukema, Jesus, Olivera; Gilmour; Neres, Anguissa, De Bruyne, McTominay; Hojlund
Match Prediction
This is going to be an entertaining contest between these clubs, but Napoli are likely to come out on top and secure a win against PSV Eindhoven in their upcoming UEFA Champions League clash.
Prediction: PSV 1-2 Napoli
Telecast Details
India: SonyLIV, Sony Sports Network
UK: TNT Sports, Amazon Prime, BBC
US: Paramount+, TUDN
Nigeria: DAZN
When and where is PSV vs Napoli UCL match?
Tuesday, October 21, 2025, at the Emirates Stadium in London, England. Kick-off is scheduled for 08:00 p.m. BST.
Where and how to watch UEFA Champions League live in India?
Sony Liv and Sony Sports Network will come up with the live streaming of all matches.
Where and how to watch UEFA Champions League live in UK?
TNT Sports, Amazon Prime, BBC will stream all the games for the fans in the UK.
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Dilpreet is a dedicated football writer with a keen eye for World Football. As a proud Real Madrid fan, we believe his work reflects the same ambition and precision. Since joining Khel Now in 2025, he has crafted stories beyond scores, diving into tactics, culture, and emotion. With a strong background in content writing, he blends clarity with creativity, always aiming to bring the beautiful game closer to readers.
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