Preview: Real Betis vs Panathinaikos Prediction, lineups, betting tips & odds | UEFA Europa League 2025-26 Round of 16 second leg

The Shamrock were the better side when they last faced Los Verdiblancos.

Real Betis will now have a face-off against Panathinaikos for their second leg round of 16 fixture of the 2025-26 UEFA Europa League. The Estadio La Cartuja is going to witness this interesting clash.

Los Verdiblancos will be at home, but it might not make things much easier for them. They have not performed well in their last few matches, making the upcoming game a tough one for them.

Real Betis need to work on their strategy and come up with a top performance. The home advantage might also help them make a comeback.

Focused and full of energy ahead of Thursday’s challenge.#MomentoRepsol pic.twitter.com/xYQ3zyFA8y

— Real Betis Balompié (@RealBetis_en) March 17, 2026

Panathinaikos are on a brilliant run of form at the moment and will be looking to put up a strong fight against Los Verdiblancos despite being away from home. The Shamrock did well in the first leg of their UEFA Europa League round of 16 contest.

They have a one-goal cushion. It is going to be one of the advantages for them.

Kick-off:

• Location: Sevilla, Spain
• Stadium: Estadio La Cartuja
• Date: Friday, March 20
• Kick-off Time: 01:30 a.m. IST (Thursday, Mar 19; 08:00 p.m. GMT/ 03:00 p.m. ET/ 12:00 p.m. PT)
• Referee: TBA
• VAR: In use

Form:

Real Betis: D-D-L-L-D

Panathinaikos: W-W-W-W-D

Players to Watch

Antony (Real Betis)

The 26-year-old has scored four goals and has three assists to his name in seven UEFA Europa League appearances this season. He is going to lead the attack from the right for Real Betis and will be a constant threat to the opponent’s defence. Antony will be eager to come up with a top performance to help his side make a comeback.

GOAT. pic.twitter.com/sVVhNO6UMD

— Real Betis Balompié (@RealBetis_en) March 17, 2026

Vicente Taborda (Panathinaikos)

Vicente Taborda will be one of the main men in the attacking front for Panathinaikos. He scored the match-winning spot kick in the previous leg, helping his side secure a win. The 24-year-old will be leading the attack from the left.

He will be looking to trouble the opponent’s side in the final third.

Match Facts

• Panathinaikos are undefeated in their last five matches.
• Real Betis are winless in their last five fixtures.
• These clubs are going to take on one another for the second time.

Real Betis vs Panathinaikos: Betting Tips and Odds

• Real Betis to win @4/9 BetFred
• Antony to score @15/8 BetVictor
• Goals under 3.5 @2/5 Unibet

Injury and Team News

Real Betis will not have Isco due to his injury and Diego Llorente because of suspension. Giovani Lo Celso and Natan Souza might also sit out due to their lack of fitness.

Giannis Kotsiras, Erik Palmer-Brown and Cyriel Dessers are not going to be in action for Panathinaikos. They are injured. Anass Zaroury is suspended.

Head-to-Head

Total matches: 1

Real Betis won: 0

Panathinaikos won: 1

Draws: 0

Predicted Lineups

Real Betis predicted lineup (4-2-3-1)

Valles (GK); Bellerin, Bartra, Natan, Firpo; Roca, Fidalgo; Antony, Fornals, Ezzalzouli; Hernandez

Panathinaikos predicted lineup (3-4-3)

Lafont (GK); Calabria, Ingason, Katris; Siopis, Sanches, Cerin, Kyriakopoulos; Pellistri, Tetteh, Taborda

Match Prediction

The hosts will be under pressure, while the Shamrock will be looking to use this to their advantage. Real Betis are likely to outplay Panathinaikos in their upcoming UEFA Europa League clash.

Prediction: Real Betis 2-0 Panathinaikos

Telecast Details

India: SonyLIV, Sony Sports Network

UK: TNT Sports

US: Paramount+, TUDN

Middle East/North Africa: beIN Sports

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