Sassuolo vs Napoli Preview, prediction, lineups, betting tips & odds | Serie A 2025-26

Gli Azzurri are the defending champions of the Italian league.
Sassuolo are ready to lock horns with Napoli in the matchweek 1 contest of the Serie A 2025-26 season. The intense game between these clubs will take place at the MAPEI Stadium.
Sassuolo are the Serie B champions who got promoted to the Italian top division league. They will be at home, feeling confident. Sassuolo Calcio are coming in after taking down Catanzaro in the first round of the Coppa Italia.
SSC Napoli are ready to begin their Serie A title defence. Antonio Conte is still the manager of the club who led them to clinch the Italian league trophy. They are coming in after a decent pre-season run and will be looking to begin the new season on a positive note.
Kick-off:
- Location: Reggio Emilia, Italy
- Stadium: MAPEI Stadium – Città del Tricolore
- Date: Saturday, August 23
- Kick-off Time: 10:00 p.m. IST/ 04:30 p.m. GMT/ 12:30 p.m. ET/ 09:30 a.m. PT
- Referee: Giovanni Ayroldi
- VAR: In use
Form:
Sassuolo: W
Napoli: N/A
Players to Watch
Domenico Berardi (Sassuolo)
Domenico Berardi will be one of the main men in the attacking front for Sassuolo as they take on the team from Naples next. The 31-year-old Italian forward will be looking to step up and come up with a top performance. Berardi will be keen on engraving his name on the scoresheet, but it is not going to be an easy task.
Kevin De Bruyne (Napoli)

After winning some trophies with Manchester City, the Belgian midfielder has now joined forces with the Serie A side Napoli. Kevin De Bruyne has been one of the top midfielders in the Premier League for years, and it will be interesting to see his performances now in Italy as the new league season is about to start.
Match Facts
- Napoli have scored 20 goals in their last five meetings against Sassuolo.
- They have managed three clean sheets in their last five fixtures against the hosts.
- Sassuolo have only scored two goals in their last five battles against Napoli.
Sassuolo vs Napoli: Betting Tips and Odds
- Napoli to win @7/12 vbet
- Lorenzo Lucca to score @17/4 Ladbrokes
- Goals over 3.5 @5/2 BetVictor
Injury and Team News
Sassuolo might miss out on the services of Kristian Thorstvedt and Ruan Tressoldi due to a lack of fitness.
Romelu Lukaku and Miguel Gutierrez are injured, hence will not be in action for Napoli.
Head-to-Head
Total matches: 23
Sassuolo won: 2
Napoli won: 14
Draws: 7
Predicted Lineups
Sassuolo predicted lineup (4-3-3)
Turati (GK); Walukiewicz, Romagna, Muharemovic, Doig; Koné, Boloca, Ghion; Berardi, Laurienté, Fadera
Napoli predicted lineup (4-4-2)
Milinkovic-Savic (GK); Di Lorenzo, Rrahmani, Jesus, Olivera; Anguissa, Lobotka, De Bruyne, McTominay; Politano, Lucca
Match Prediction
These clubs are set to produce an interesting contest, and the winning team will get to have three important points. Napoli are likely to emerge victorious against Sassuolo in their opening Serie A 2025-26 match.
Prediction: Sassuolo 1-3 Napoli
Telecast Details
India: TBA
Italy: Sky Sports, Not TV, DAZN
UK: DAZN
USA: Paramount+, DAZN
When and where is Sassuolo vs Napoli Serie A 2025-26 match?
Saturday, August 23, 2025, at the MAPEI Stadium – Città del Tricolore in Reggio Emilia, Italy. Kick-off is scheduled for 05:30 p.m. BST.
Where and how to watch Serie A 2025-26 in India?
No broadcaster has the right to telecast the top flight of Italian football in India as of now.
Where and how to watch Serie A 2025-26 in Italy?
People in Italy will be able to watch the matches live on Sky Sports, Now TV and DAZN.
Where and how to watch Serie A 2025-26 in UK?
Fans can tune into DAZN to watch all the matches live.
Where and how to watch Serie A 2025-26 in USA?
Paramount+ and DAZN can be used to watch all the fixtures live.
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Dilpreet is a dedicated football writer with a keen eye for World Football. As a proud Real Madrid fan, we believe his work reflects the same ambition and precision. Since joining Khel Now in 2025, he has crafted stories beyond scores, diving into tactics, culture, and emotion. With a strong background in content writing, he blends clarity with creativity, always aiming to bring the beautiful game closer to readers.
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