Preview: Southampton vs Arsenal Prediction, lineups, betting tips & odds | FA Cup 2025-26 quarter-final

Two of the last five meetings between these sides have ended in a draw.

Southampton are all set to lock horns with Arsenal for their quarterfinal outing of the 2025-26 FA Cup. St. Mary’s Stadium is going to witness this entertaining fixture.

The Saints have secured back-to-back wins in their last three matches and will only be looking to extend their winning run. The Tonda Eckert-led side have performed well in their last few matches and will be eager to come up with another top performance. Southampton FC are going to be at home for their upcoming outing, but it is not going to be an easy one for them.

Mikel Arteta’s men were completely outplayed in their Carabao Cup final against Manchester City. It was an underwhelming performance by them.

They will now be looking to return to winning ways. Arsenal will be away from home for their FA Cup game against the Saints, but they will be keen to put up a strong fight.

Kick-off:

• Location: Southampton, England
• Stadium: St. Mary’s Stadium
• Date: Sunday, April 5
• Kick-off Time: 12:30 AM IST (Saturday, April 4; 07:00 PM GMT/ 02:00 PM ET/ 11:00 AM PT
• Referee: Samuel Barrott
• VAR: In use

Ready for the run-in ✊ pic.twitter.com/yPKvpLkTbq

— Arsenal (@Arsenal) March 31, 2026

Form:

Southampton: W-D-W-W-W

Arsenal: W-D-W-W-L

Players to Watch

Cyle Larin (Southampton)

The 30-year-old will be looking to step up his game so that he can help his side stand a chance against the Gunners. He was one of the goal scorers for Southampton in their last league outing. Cyle Larin is going to lead the attack from the front for the Saints and will be looking to come up with a top performance here.

Viktor Gyokeres (Arsenal)

Viktor Gyokeres helped the Sweden national football team to secure a spot in the FIFA World Cup 2026 after a couple of strong performances during the recent international break. The 27-year-old will be looking to use this momentum for Arsenal now. He is going to be a constant threat to the opponent’s defence.

Match Facts

• Southampton FC are on a 14-match unbeaten run.
• Arsenal have secured three wins in their last five games.
• The Saints have only secured one win in their last five outings against the Gunners.

Southampton vs Arsenal: Betting Tips and Odds

• Arsenal to win @3/10 Ladbrokes
• Viktor Gyokeres to score @15/13 Unibet
• Goals under 3.5 @8/13 William Hill

Injury and Team News

Southampton will not have Mads Roerslev in action. He is injured. They might also miss out on Leo Scienza, Welington and Jay Robinson due to their fitness issues.

Eberechi Eze and Mikel Merino are not going to be in action for Arsenal. They are injured and are likely to return in April-May 2026.

Bukayo Saka, Martin Odegaard, Martin Zubimendi, Jurrien Timber, William Saliba, Gabriel Magalhaes, Leandro Trossard, Noni Madueke, Piero Hincapie and Declan Rice are not confirmed to be a part of the squad.

Head-to-Head

Total matches: 108

Southampton won: 23

Arsenal won: 55

Draws: 30

Predicted Lineups

Southampton predicted lineup (4-2-3-1)

Peretz (GK); Bree, Harwood-Bellis, Stephens, Manning; Downes, Charles; Fellows, Archer, Azaz; Larin

Arsenal predicted lineup (4-2-3-1)

Raya (GK); White, Mosquera, Calafiori, Lewis-Skelly; Norgaard, Dowman; Jesus, Havertz, Martinelli; Gyokeres

Match Prediction

The Saints are potentially going to make things tougher for the visitors on home soil. The Gunners, with their fluid playing style, are surely going to create problems for the hosts. If Arsenal maintain their composure and control of possession, they might come out on top to secure a win against Southampton FC.

Prediction: Southampton 1-2 Arsenal

Telecast Details

India: Sony LIV, Sony Sports Network

UK: TNT Sports, BBC

USA: ESPN+

Nigeria: StarTimes

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