Tottenham Hotspur vs Villarreal Preview, prediction, lineups, betting tips & odds | UEFA Champions League 2025-26

The Yellow Submarine emerged victorious when they last faced the Spurs.
Tottenham Hotspur are all set to host Villarreal in the matchweek 1 league phase fixture of the 2025-26 UEFA Champions League. The interesting contest between the two clubs will take place at the Tottenham Hotspur Stadium.
Tottenham Hotspur won the UEFA Europa League title, which helped them secure a spot in the UCL for this season. Spurs performed well to secure a major title after 17 years. The Lillywhites will be looking to begin their Champions League campaign on a positive note.
The LaLiga side Villarreal began their new season on a positive note. But in their last league fixture, they fell prey to Atletico Madrid. It was an underwhelming performance by the Submarines.
They will be the visiting side for the opening UEFA Champions League game and might be low on confidence here.
Kick-off:
- Location: London, England
- Stadium: Tottenham Hotspur Stadium
- Date: Wednesday, September 17
- Kick-off Time: 12:30 a.m. IST (Tuesday, September 16; 07:00 p.m. GMT/ 03:00 p.m. ET/ 12:00 p.m. PT)
- Referee: Rade Obrenović
- VAR: In use
Form:
Tottenham: W-W-L-W
Villarreal: W-W-D-L
Players to Watch
Randal Kolo Muani (Tottenham Hotspur)
The Frenchman was not a part of Tottenham’s squad in their Premier League game against West Ham United. Still, he is going to play an important role in the attacking front for the hosts. Randal Kolo Muani joined Juventus last season on a loan deal, where he performed well.
He is now a part of the Spurs, and a player of his quality can be a thorn for the opponents.
Tajon Buchanan (Villarreal)
Tajon Buchanan has already scored a hat-trick for Villarreal in the new season. The 26-year-old forward from Canada has been in decent form for the Spanish side and is going to play a crucial part in the final third. He will be looking to step up for his side so that he can score a goal or two.
Match Facts
- This will be the second-ever confrontation between these clubs.
- Tottenham have won three of their last four matches.
- Villarreal have won two of their previous four fixtures.
Tottenham vs Villarreal: Betting Tips and Odds
- Tottenham Hotspur to win @93/100 10bet
- Randal Kolo Muani to score @11/2 bet365
- Goals under 3.5 @5/12 Unibet
Injury and Team News

Dominic Solanke, Dejan Kulusevski, James Maddison, Kota Takai and Radu Dragusin are injured. Hence, they will not be in action for the Spurs. Yves Bissouma might also miss out due to a lack of fitness.
Villarreal will be without the services of Gerard Moreno, Logan Costa and Pau Cabanes as they are injured. Willy Kambwala might also miss out due to fitness issues.
Head-to-Head
Total matches: 1
Tottenham won: 0
Villarreal won: 1
Draws: 0
Predicted Lineups
Tottenham predicted lineup (4-3-3)
Vicario (GK); Porro, Romero, Van de Van, Spence; Sarr, Palhinha, Bergvall; Kudus, Kolo Muani, Simons
Villarreal predicted lineup (4-4-2)
Luiz Junior (GK); Mourino, Foyth, Veiga, Cardona; Buchanan, Partey, Parejo, Moleiro; Pepe, Mikautadze
Match Prediction
This will be an interesting fixture between these sides as they have only faced each other once before. Tottenham are likely to emerge victorious against Villarreal in their opening UEFA Champions League clash.
Prediction: Tottenham 2-1 Villarreal
Telecast Details
India: SonyLIV, Sony Sports Network
UK: TNT Sports, BBC
US: Paramount+, TUDN
Nigeria: DAZN
When and where is Tottenham vs Villarreal UCL match?
Tuesday, September 16, 2025, at the Tottenham Hotspur Stadium in London, England. Kick-off is scheduled for 08:00 p.m. BST.
Where and how to watch UCL 2025-26 in India?
SonyLIV and Sony Sports Network can be used to watch the UCL in India.
Where and how to watch UCL 2025-26 in UK?
Fans can tune into TNT Sports and BBC to watch all the games live.
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Dilpreet is a dedicated football writer with a keen eye for World Football. As a proud Real Madrid fan, we believe his work reflects the same ambition and precision. Since joining Khel Now in 2025, he has crafted stories beyond scores, diving into tactics, culture, and emotion. With a strong background in content writing, he blends clarity with creativity, always aiming to bring the beautiful game closer to readers.
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