Naomi Osaka vs Amanda Anisimova prediction, betting tips & odds, head-to-head, preview: US Open 2025

Naomi Osaka is yet to beat Anisimova in two meetings.

Amanda Anisimova produced the biggest upset of the 2025 US Open so far, defeating No. 2 seed and reigning Wimbledon champion Iga Swiatek 6-4, 6-3 in the quarter-finals.

Just 53 days after suffering a crushing 6-0, 6-0 loss to Swiatek in the Wimbledon final, the American used the backing of the local crowd to flip the script with fearless, aggressive hitting that kept the Pole on the defensive.

Swiatek admitted her struggles with serve—landing only 50% of first serves, while the American praised her own positive mindset and refusal to play with fear. The win not only avenged her Wimbledon humiliation but also highlighted Anisimova’s resilience and ability to rise on the biggest stages.

Amanda Anisimova avenges her Wimbledon loss to Swiatek less than two months ago 😤 She's headed to her first US Open Semifinal 👏 pic.twitter.com/kmht6BGl4q

— SportsCenter (@SportsCenter) September 3, 2025

Naomi Osaka continued her impressive comeback with a 6-4, 7-6(3) victory over Karolina Muchova in the US Open quarter-finals, returning to a Grand Slam semi-final for the first time since becoming a mother.

The two-time US Open champion showcased both her trademark power and newfound patience, weathering Muchova’s aggressive shot-making while staying composed in long rallies.

Having won the title every time she’s reached a major quarter-final, Osaka now heads into a highly anticipated semi-final clash with Anisimova, brimming with confidence and belief.

Match details

• Tournament: US Open 2025
• Round: Semi-final
• Date: September 4
• Venue: Arthur Ashe Stadium, Flushing Meadows
• Surface: Hard

Also read: Aryna Sabalenka vs Jessica Pegula prediction, betting tips & odds, head-to-head, preview: US Open 2025

​Preview

15th seed Daria Kasatkina, third seed Coco Gauff, and 11th seed Karolina Muchova are the victims of Naomi Osaka’s brutality so far at the Flushing Meadows, and the Japanese is not stopping any time soon. Next up is eighth seed and three-time Grand Slam semi-finalist Anisimova.

The American has enjoyed considerable success this year, with consecutive Grand Slam final four appearances. She moreover has dominated her match-up against Osaka, winning both their battles which have occurred in major events.

In 2022, they met at the Australian Open and Roland Garros, with Anisimova prevailing in convincing fashion. With the crowd expected to cheer for both players, this duel between both hard-hitters is expected to keep tennis fans on the edge of their seat.

Form

• Naomi Osaka: W-W-W-W-W
• Amanda Anisimova: W-W-W-W-W

Head-to-head record

• Matches: 2
• Naomi Osaka: 0
• Amanda Anisimova: 2

Look who is back.Naomi Osaka has returned the US Open semifinals. pic.twitter.com/qujVkuSX1X

— US Open Tennis (@usopen) September 4, 2025

Stats

Naomi Osaka

• Osaka has a 32-12 win-loss record in the 2025 season
• Osaka has a 28-6 win-loss record in New York
• Osaka has won 68% of matches played on hard courts

Amanda Anisimova

• Anisimova has a 39-16 win-loss record in the 2025 season
• Anisimova has a 8-5 win-loss record in New York
• Anisimova has won 62% of matches played on hard courts

Also read: US Open 2025: All you need to know about prize money & points on offer

Naomi Osaka vs Amanda Anisimova: Betting tips and odds

• Moneyline: Osaka -118, Anisimova +110
• Spread: Osaka -0.5 (-115), Anisimova +1.5 (-125)
• Total Games: Over 21.5 (-120), Under 22.5 (-120)
• 1st Set Winner: Osaka -115, Anisimova +100
• 1st Set Total Games: Over 8.5 (-325), Under 9.5 (-120)

Match prediction

Osaka and Anisimova meet in a blockbuster US Open semi-final, both returning to the big stage after battling setbacks in recent years. Anisimova, the first-time semi-finalist, rides the confidence of her stunning win over Iga Swiatek, showcasing fearless ball-striking and a lethal backhand.

Meanwhile, Osaka, a four-time Grand Slam winner, has rediscovered her sharp serving, patience in rallies, and big-match aura—qualities that once made her unbeatable in New York.

This clash promises explosive hitting, short points, and plenty of tension under the Arthur Ashe lights. Anisimova’s power and home support will test Osaka, but the Japanese star’s experience and ability to raise her level in defining moments should carry her through.

Result: Amanda Anisimova to win in three sets.

Where and how to watch live telecast and live streaming of Naomi Osaka vs Amanda Anisimova, semi-final match at 2025 US Open?

The semi-final clash will be available for Indian viewers on Jio Hotstar and Star Sports. Sky UK and the Tennis Channel will broadcast the face-off live within the United Kingdom and the United States, respectively.

For full worldwide broadcast details click here

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