DC United vs Charlotte FC Preview, prediction, lineups, betting tips & odds | US Open Cup 2025

The Crown dominated the Black and Red Eagles when the last time both sides battled.
D.C. United are ready to host Charlotte FC in round of 16 of the US Open Cup 2025. The intense, high-stakes fixture between the two MLS sides is all set to take place at the Audi Field.
Despite being at home, D.C. United will be feeling pressurised as they were dominated by the Crown in their last meeting against them. The Black and Red Eagles will be looking to give their all here and it is not going to be an easy task for them. They are not doing well in the Major League Soccer either, as they are in the 12th spot on the Eastern Conference points table.
Charlotte FC are in eighth spot on the Eastern Conference MLS points table. They have come up with some average performances till now, but they will now be looking to step up as they have a chance to make it to the quarter-final stage of the US Open Cup this year.
Kick-off:
- Location: Washington, District of Columbia
- Stadium: Audi Field
- Date: Thursday, May 22
- Kick-off Time: 05:00 IST (Wednesday, May 21; 23:30 GMT/ 18:30 ET/ 15:30 PT)
- Referee: TBD
- VAR: Not in use
Form:
D.C. United: W-W-L-D-D
Charlotte FC: L-W-L-L-L
Players to Watch
Jared Strout (D.C. United)
Jared Strout is going to play an essential role in the final third for the Black and Red Eagles. He doubled the lead for DC United, which helped them secure an easy win. It is going to be a tough game for the hosts and they are also lacking in the attacking front as of now, but Strout might turn the tide for them here.
Kerwin Vargas (Charlotte FC)
The 23-year-old Colombian forward has two goal contributions in just a single US Open Cup fixture for Charlotte FC. Although the Crown are not looking in good touch at the moment, Kerwin Vargas will play an important role in the squad, which will help them in the attacking front.
Match Facts
- Charlotte FC are on a three-match losing streak.
- The Crown have won three of their last five matches against DC United.
- The Black and Red Eagles are unbeaten in their last two games.
D.C. United vs Charlotte FC: Betting Tips and Odds
- Charlotte FC to win @6/4 bet365
- Kerwin Vargas to score @8/1 Skybet
- Goals over 3.5 @2/1 Skybet
Injury and Team News
Christian Benteke, Dominique Badji and a couple of more DC United players are injured, hence keeping them out of action.
Charlotte FC will be without the services of Souleyman Doumbia, Brandon Cambridge and five other players as they have injuries.
Head-to-Head
Total matches: 6
D.C. United won: 2
Charlotte FC won: 3
Draws: 1
Predicted Lineups
D.C. United predicted lineup (3-4-3)
Joon-Hong (GK); Peltola, Tubbs, Rowles; Dodson, Servania, Enow, Schnegg; Karamoko, Stroud, Kijima
Charlotte FC predicted lineup (4-4-2)
Bingham (GK); Scardina, Tuiloma, Privett, Marshal-Rutty; Vargas, Diani, Williamson, Smalls; Agyemang, Tavares
Match Prediction
Both Major League Soccer sides are ready for an intense battle here, but it will be Charlotte FC who will emerge as the better team in the upcoming US Open Cup 2025 round of 16 clash.
Prediction: D.C. United 1-3 Charlotte FC
Telecast Details
USA: Paramount+
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Dilpreet is a dedicated football writer with a keen eye for World Football. As a proud Real Madrid fan, we believe his work reflects the same ambition and precision. Since joining Khel Now in 2025, he has crafted stories beyond scores, diving into tactics, culture, and emotion. With a strong background in content writing, he blends clarity with creativity, always aiming to bring the beautiful game closer to readers.
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