Real Betis vs Lyon Preview, prediction, lineups, betting tips & odds | UEFA Europa League 2025-26

Les Gones emerged victorious when they last faced Los Verdiblancos.

Real Betis are all set to battle it out against Lyon in their round 4 league phase match of the UEFA Europa League 2025-26 season. Estadio La Cartuja de Sevilla will witness the interesting contest between these clubs.

Los Verdiblancos have performed well in their last two games, and they will be keen to continue their form going forward. Real Betis have only won one of their first three games of the European competition. The LaLiga side will be at home, but it is not going to be an easy contest for them.

Les Gones have emerged victorious in all of their UEFA Europa League matches this season. Olympique Lyonnais have performed decently in their last few matches across all competitions. The Ligue 1 side will be looking to extend their winning run in the UEL.

Kick-off:

• Location: Sevilla, Spain
• Stadium: Estadio La Cartuja de Sevilla
• Date: Friday, November 7
• Kick-off Time: 01:30 a.m. IST (Thursday, Nov 6; 08:00 p.m. GMT/ 04:00 p.m. ET/ 01:00 p.m. PT)
• Referee: Matej Jug
• VAR: In use

Form:

Betis: D-D-L-W-W

Lyon: L-W-W-D-D

Players to Watch

Antony (Real Betis)

The 25-year-old is going to play an important role in the attacking front for Real Betis. Antony is coming in after scoring a sensational brace and also bagging an assist for Los Verdiblancos in their LaLiga match against Mallorca. He is going to be a constant threat to the opponent’s defence.

Antony vs Mallorca83 minutes2 goals1 assistYou can't hate him 🐐 pic.twitter.com/czQAgN9gNi

— Real Betis Balompié (@RealBetis_en) November 2, 2025

Pavel Sulc (Lyon)

Pavel Sulc is going to play a crucial part both in the midfield and the attacking front for Olympique Lyonnais. He is going to lead the attack from the right and also control the ball well in the midfield. Sulc can score goals as well, which is going to become a problem for Betis.

Match Facts

• Real Betis are on a two-match winning streak.
• Lyon are unbeaten in their last four matches.
• Los Verdiblancos have never won a match against Les Gones.

Real Betis vs Lyon: Betting Tips and Odds

• Real Betis to win @93/100 10bet
• Antony to score @15/2 Spread Ex
• Goals under 3.5 @4/9 bet365

Injury and Team News

Junior Firpo will be in action for Real Betis as he is injured. Isco is back in training, but his availability is not yet confirmed. Ricardo Rodriguez, Pau Lopez and Ezequiel Avila might also miss out due to fitness issues.

Lyon will miss out on the services of Orel Mangala, Ernest Nuamah and Malick Fofana as they are injured.

Head-to-Head

Total matches: 2

Real Betis won: 0

Lyon won: 1

Draws: 1

Predicted Lineups

Real Betis predicted lineup (4-2-3-1)

Valles (GK); Bellerín, Bartra, Natan, Gomez; Amrabat, Fornals; Antony, Lo Celso, Ezzalzouli; Hernández

Lyon predicted lineup (4-2-3-1)

Greif (GK); Hateboer, Mata, Niakhaté, Tagliafico; Tessmann, Morton; Sulc, Tolisso, Moreira; Satriano

Match Prediction

These clubs are going to come up with an intense battle against each other, but it will be Real Betis who are likely to come out on top to secure a win against Lyon in their upcoming UEFA Europa League clash.

Prediction: Real Betis 2-1 Lyon

Telecast Details

India: SonyLIV, Sony Sports Network

UK: TNT Sports

US: Paramount+, TUDN

Middle East/North Africa: beIN Sports

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