San Jose Earthquakes vs Portland Timbers Preview, prediction, lineups, betting tips & odds | US Open Cup 2025

The Quakes dominated the proceedings the last time both sides battled.
San Jose Earthquakes are all set to host the Portland Timbers in the round of 16 of the US Open Cup 2025 edition. The PayPal Park will witness the clash between the two Major League Soccer sides.
San Jose Earthquakes are coming in after defeating Sacramento Republic FC in a close matchup. They have also shown some average performances in the MLS this season. They are in the eighth spot in the league table at the moment.
Portland Timbers are in fourth place on the MLS Western Conference table. They will be looking to step up here in their upcoming US Open Cup fixture. The Timbers secured a close win against Tacoma Defiance in their round of 32 fixture. They came in with a late strike to secure a win.
Kick-off:
- Location: San Jose, California
- Stadium: PayPal Park
- Date: Wednesday, May 21
- Kick-off Time: 08:00 IST/ 02:30 GMT / Tuesday, May 20: 21:30 ET/ 18:30 PT
- Referee: TBD
- VAR: Not in use
Form:
San Jose Earthquakes: W-W-W-D-D
Portland Timbers: L-W-W-D-D
Players to Watch
Josef Martinez (San Jose Earthquakes)
The 31-year-old forward, hailing from Venezuela, is going to play a crucial role in the attacking front for the Quakes. The hosts have a good attacking rate, and Josef Martinez is likely to cause problems for the opponent’s defence. He has seven goal contributions in 11 MLS games this season.
Santiago Moreno (Portland Timbers)
Santiago Moreno is coming in after scoring an important equaliser for the Timbers in their last MLS fixture against the Seattle Sounders. The 25-year-old Colombian forward is going to play an important role in the attacking front for his side. He is yet to open the scoring in the US Open Cup.
Match Facts
- Portland Timbers have secured four wins in their last five matches against the San Jose Earthquakes.
- They have lost one of their last five games.
- San Jose Earthquakes are on a five-match unbeaten run.
San Jose Earthquakes vs Portland Timbers: Betting Tips and Odds
- San Jose Earthquakes to win @29/20 bet365
- Goals over 3.5 @5/4 10 bet
- Cristian Arango to score
Injury and Team News
Cristian Arango, Niko Tsakiris, Noel Buck and Rodrigues are injured, hence keeping them out of action for San Jose Earthquakes.
Portland Timbers will be without the services of Diego Chara, James Pantemis, Kevin Kelsy and Zac McGraw as they have injuries.
Head-to-Head
Total matches: 40
San Jose Earthquakes won: 7
Portland Timbers won: 22
Draws: 11
Predicted Lineups
San Jose Earthquakes predicted lineup (3-4-3)
Daniel (GK); Floriani, Munie, Roberts; Lima, Fernandez, Kaye, Ricketts; Martinez, Judd, Pellegrino
Portland Timbers predicted lineup (4-4-2)
Crepeau (GK); Mosquera, Surman, Miller, Fory; Moreno, Ortiz, Ayala, Antony; Mora, Da Costa
Match Prediction
Even though the Timbers have a positive record against the Quakes, it should be the San Jose Earthquakes who are likely to emerge victorious against the Portland Timbers in the US Open Cup 2025 round of 16 clash.
Prediction: San Jose Earthquakes 3-2 Portland Timbers
Telecast Details
USA: Paramount+
For more updates, follow Khel Now on Facebook, Twitter, and Instagram; download the Khel Now Android App or IOS App and join our community on Telegram.

Dilpreet is a dedicated football writer with a keen eye for World Football. As a proud Real Madrid fan, we believe his work reflects the same ambition and precision. Since joining Khel Now in 2025, he has crafted stories beyond scores, diving into tactics, culture, and emotion. With a strong background in content writing, he blends clarity with creativity, always aiming to bring the beautiful game closer to readers.
- Top nine WWE superstars who are avid football/soccer fans
- Lamine Yamal denies rumours of dating 30-year-old influencer: Report
- Manchester United CEO Omar Berrada doubles down on timeline for Premier League title
- Liverpool to get new sister club? FSG interested in acquiring LaLiga side Getafe: Report
- Barcelona strike pre-agreement with Nico Williams: Report
- Top nine WWE superstars who are avid football/soccer fans
- Top five football stars missing at FIFA Club World Cup 2025
- Top 10 players with most minutes played since start of 2020-21 season
- Top five countries with most FIFA Club World Cup trophies
- Players who could debut for their new clubs at FIFA Club World Cup 2025