Orlando City vs Nashville SC Preview, prediction, lineups, betting tips & odds | US Open Cup 2025

The Lions dominated the proceedings against the Boys in Gold when the last time both sides clashed.

Orlando City SC are all set to host Nashville SC in the Round of 16 of the US Open Cup 2025 edition. The high-stakes contest between the two Major League Soccer teams will take place at Inter&Co Stadium.

Orlando City will be at home, which will be a big advantage for them. They are doing decent enough in the MLS as well. They are coming in after defeating Lionel Messi‘s Inter Miami in their last league fixture. This will keep them confident when they go up against the Boys in Gold in the US Open Cup fixture.

Nashville SC will be away from home and they will be under pressure as well. They have put up a poor show against the Lions in their last few meetings. This will keep the confidence levels for Nashville on the lower side. A win can get them through to the quarterfinals, but it is not going to be an easy clash.

Kick-off:

• Location: Orlando, Florida
• Stadium: Inter&Co Stadium
• Date: Thursday, May 22
• Kick-off Time: 05:00 IST; Wednesday, May 21; 23:30 GMT/ 18:30 ET/ 15:30 PT
• Referee: TBD
• VAR: Not in use

Form:

Orlando City: D-W-D-W-W

Nashville SC: D-W-W-W-D

Players to Watch

Luis Muriel (Orlando City)

The 34-year-old Colombian forward is coming in after scoring an important goal for the Lions in their previous fixture against the Herons. Luis Muriel came up with a good performance and will be looking to help Orlando City on the attacking front yet again. He is yet to score in the US Open Cup.

Hany Mukhtar (Nashville SC)

Despite being a midfielder, Hany Mukhtar has an important role to play in the attacking front for the Boys in Gold. He has six goal involvements in the last five MLS games and this time he will be looking to step up for the cup fixture clash against the Lions. It is not going to be an easy contest, but Mukhtar might emerge as the game changer.

Match Facts

• Orlando City have not lost any of their last 12 matches.
• Nashville SC are unbeaten in all of their last six games.
• The Lions are on a five-match winning streak against the Boys in Gold.

Orlando City vs Nashville SC: Betting Tips and Odds

• Orlando City to win @23/20 10 bet
• Goals over 3.5 @12/5 Skybet
• Luis Muriel to score

Injury and Team News

Orlando City will be without the services of Eduard Atuesta, Nicolas Rodriguez and Yutaro Tsukada as they are injured.

Nashville SC will miss out on Tyler Boyd, Walker Zimmerman and three other players because of their injuries.

Head-to-Head

Total matches: 14

Orlando City won: 6

Nashville SC won: 3

Draws: 5

Predicted Lineups

Orlando City predicted lineup (4-2-3-1)

Gallese (GK); Freeman, Schlegel, Jansson, Brekalo; Araujo, Gerbet; Pasalic, Ojeda, Angulo; Muriel

Nashville SC predicted lineup (4-2-3-1)

Willis (GK); Najar, Palacios, Maher, Lovitz; Yazbek, Tagseth; Shaffelburg, Mukhtar, Muyl; Surridge

Match Prediction

The Lions are on a positive run and so are Boys in Gold, but it will be Orlando City SC who are likely to defeat Nashville SC in their upcoming US Open Cup 2025 round of 16 fixture.

Prediction: Orlando City 3-2 Nashville SC

Telecast Details

USA: Paramount+

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